Our paper entitled “Thirteen Concepts to Play it Safe with the Cloud” has been accepted at IEEE International Systems Conference (SysCon), that will take place in Vancouver, Canada on April 17-20, 2023. The paper discusses how edge and cloud technologies has the potential to enhance safety-critical CPS, also in regulated environments. This is only possible when safety, performance, cyber security, and privacy of data are kept at the same level as in on-device only safety-critical CPS. To this end, this paper presents thirteen selected safety and performance concepts for distributed device-edge-cloud CPS solutions. This early result of the TRANSACT project aims to ensure needed end-to-end performance and safety levels from an end-user perspective, to extend edge and cloud benefits of more rapid innovation and inclusion of value-added services, also to safety-critical CPS.